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. 2011 Dec 9;13(1):36–43. doi: 10.1038/embor.2011.231

Figure 2.

Figure 2

FBW7 is required for neural stem cell differentiation. FBW7 controls NSC differentiation through downregulation of its ubiquitin substrates, such as Notch 1. Loss of FBW7 leads to impaired NSC differentiation due to the upregulation of c-Jun, Notch 1, Notch 3 and the Notch target genes Hes1, Hes5, Hey1 and Hey2. After deletion of FBW7, differentiation of NSCs is skewed towards astrocytes at the expense of neurons, suggesting that excessive and persistent Notch signalling impairs the differentiation of NSCs to neurons. FBW7, F-box and WD-repeat-domain-containing 7; Hes, hairy and enhancer of split 1; Hey, hairy/enhancer-of-split related with YRPW motif protein 1; NSC, neural stem cell.