Table 1.
miRNAs involved in neurological disorders.
| Neurological disorders |
miRNAs | Proven targets |
Potential mechanisms | References |
|---|---|---|---|---|
| Tourette's syndrome | miR-189 | SLITRK1 | Mutation at the binding site for miR-189 in the target 3’UTR | [91] |
| Fragile X syndrome | miR-19b, miR-302b*, miR-323-3p | FMRP | Repression of FMR1 expression level | [93] |
| Schizophrenia | miR-181b, miR-219 |
VSNL1, GRIA2#CaMKIIγ | Upregulation of miR-181b in Schizophrenia NMDA signaling and miR-219 forming a feedback loop in Schizophrenia |
[98] [99] |
| Alzheimer's disease (AD) | miR-107 miR-29a/b miR-298, miR-328 miR-101 miR-146a |
BACE1 BACE1 BACE1 APP CFH |
Downregulation of miR-107 and increase of its target BACE1 in AD Downregulation of miR-29a/b and increase of its target BACE1 in AD Repression of BACE1 expression and accumulation of Aβ Repression of APP expression and accumulation of Aβ Downregulation of miR-146a in AD |
[105] [106] [108] [109] [110] |
| Huntington's disease (HD) | miR-9 miR-9* miR-34b |
REST CoREST ? |
Upregulation of miR-9/9* in HD A potential biomarker for HD |
[114] [115] |
| Parkinson’s disease (PD) | miR-7 miR-153 miR-433 |
α-synuclein FGF20 |
Repression of α-synuclein accumulation A SNP in the miR-433 binding site of FGF20 3’UTR in AD |
[116] [118] |
| Prion disease | miR-191 miR-342-3p, miR-320, let-7b, miR-328, miR-128, miR-139-5p, miR-146a, miR-337-3p, miR-338-3p |
EGR1 ? |
De-regulation after infection with mouse-adapted scrapie | [119] |
| Down’s syndrome (DS) | miR-155, miR-802 miR-125b |
MeCP2 CDKN2A |
Upregulation of miR-155 and miR-802 in DS and suppression of MeCP2 Upregulation of miR-125b in DS and suppression of CDKN2A |
[124] [125] |
| Stroke | miR-21 miR-124a |
FASLG JAG1 |
Upregulation of miR-125b in Stroke and suppression of FASLG Downregulation of miR-124a after Stroke |
[127] [128] |
| Epilepsy | miR-146a | ? | Upregulation after TLE | [129] |
| Depression and bipolar disorder (BD) | miR-182 miR-30e miR-134 miR-16 miR-34a |
ADCY6, CLOCK, DSIP ? ? SERT GRM7 |
Polymorphism in the rs76481776 of the pre-miR-182 Polymorphism in the ss178077483 of the pre-miR-30e A potential biomarker for bipolar disorders Upregulation of miR-16 after SSRI treatment Downregulation of miR-34a after treatment using mood stabilizers |
[130] [131] [133] [134] [135] |