Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Proposed model of increased AMPK activity during prolonged wakefulness. Prolonged wakefulness such as sleep deprivation activates central AMPK via decreased AMP/ATP ratio or increased CaMkk2 expression. An activation of AMPK enhances energy-producing catabolic pathways and attenuates energy-consuming anabolic pathways.
