Table 1.

Baseline characteristics and details of meningitis in 10 patients coinfected with HIV and TB.

Patient	Age, years	Gender	SAPiT arm	CD4+ cell count, cells/mm3	First AIDS defining condition	Previous TB	Previous meningitis	Aetiology of meningitis	Recurrent Meningitisa (time from first episode, days)	ART	Presenting clinical features	Outcome
1	31	F	Early	65	Yes	Yes	No	Cryptococcal	No	Yes	Headache, neck stiffness, photophobia	Recovered
2	30	F	Postcontinuation	298	Yes	No	No	Cryptococcal	No	Yes	Headache, neck stiffness, vomiting, photophobia	Recovered
3	45	F	Early	2	Yes	Yes	No	Cryptococcal & acute bacterial	No	Yes	Headache, neck stiffness, photophobia, confusion	Recovered
								Cryptococcal	Yes— cryptococcal (39 days)	Yes	Cutaneous cryptococcal lesions	Recovered
4	48	M	Postcontinuation	54	Yes	No	No	Cryptococcal	No	No	Headache, fever	Recovered, death from cerebral glioma
5	33	M	Postintensive	12	Yes	No	No	Cryptococcal	No	No	Headache, neck stiffness, vomiting	Recovered
								Cryptococcal	Yes—cryptococcal (40 days)	No	Headache, neck stiffness vomiting	Recovered, death from lung abscess
6	33	M	Postcontinuation	2	Yes	Yes	No	Cryptococcal	No	Yes	Headache, neck stiffness, confusion	Death
7	24	M	Postintensive	18	Yes	No	No	Cryptococcal	No	No	Headache, neck stiffness, vomiting	Recovered
								Cryptococcal	Yes—cryptococcal (126 days)	Yes	Headache, neck stiffness, vomiting, fever	Recovered with neurological impairment
								Cryptococcal & Tuberculous	Yes—Tuberculous and cryptococcal (188 days)	Yes	Headache, neck stiffness, fever, focal signs	Death
8	34	M	Early	8	Yes	No	No	Tuberculous	No	No	Headache, neck stiffness, photophobia, loss of appetite	Recovered, death from pneumonia
9	33	M	Early	7	No	Yes	Yes	Tuberculous	No	Yes	Headache, neck stiffness, confusion, focal signs	Death
10	26	F	Postcontinuation	14	No	Yes	Yes	Tuberculous	No	Yes	Neck stiffness, confusion	Death

^aRecurrent meningitis refers to cases of meningitis that occurred during the follow-up period.

Note. All cases of cryptococcal meningitis were confirmed by a positive India ink stain or positive cryptococcal antigen test on CSF. The diagnoses of tuberculous meningitis were based on clinical features and CSF abnormalities in keeping with our case definition. Mycobacterium tuberculosis was not isolated in the CSF in any of these cases.