Figure 12.

Insulin receptor kinase–pyrrolopyridine complex (PDB code 3eta) with the interaction network hot spot originating from a solvent-exposed amino group. The numbers in the figure indicate the atom-based Scorpion score and network contribution of the terminal amino group. The X-ray crystal structure is with the insulin receptor kinase, while the SAR was obtained from IGF-1R tyrosine kinase. They have a sequence identity of 80% in their kinase domains and have no amino acid differences within 5 Å of the ligand.