Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Illustration of an unfavorable protein–ligand contact with a potential desolvation penalty in factor Xa. With R = NHCH2CHF2 the Ki against factor Xa is 1100 nM, while with R = OCH2CHF2 the Ki is 21 nM. The model is built on the basis of the X-ray structure of the close analogue R = OCH3 by replacing O with NH and H with CHF2, respectively (PDB code 2vvc).(58)
