Table 3.
Correlation Between OLFM4, S100B, and TM4SF3 Gene Expression and Clinicopathological Properties of 103 Postoperative Colorectal Cancer Patients
| |
|
OLFM4 overexpressiona |
S100B overexpressiona |
TM4SF3 overexpressiona |
|||
|---|---|---|---|---|---|---|---|
| Variables | Total cases | +35 | −68 | +12 | −91 | +14 | −89 |
| Gender | |||||||
| Male | 58 (56.3%) | 22 (37.9%) | 36 (62.1%) | 8 (13.8%) | 50 (86.2%) | 9 (15.5%) | 49 (84.5%) |
| Female | 45 (43.7%) | 13 (28.9%) | 32 (71.1%) | 4 (8.9%) | 41 (91.1%) | 5 (11.1%) | 40 (88.9%) |
| p-Value | 0.337 | 0.544 | 0.518 | ||||
| Age (years) | |||||||
| <60 | 62 (60.2%) | 19 (30.6%) | 43 (69.4%) | 4 (6.5%) | 58 (93.5%) | 6 (9.7%) | 56 (90.3%) |
| ≥60 | 41 (39.8%) | 16 (39.0%) | 25 (61.0%) | 8 (19.5%) | 33 (80.5%) | 8 (19.5%) | 33 (80.5%) |
| p-Value | 0.379 | 0.060 | 0.154 | ||||
| Tumor Size | |||||||
| <5cm | 48 (46.6%) | 16 (33.3%) | 32 (66.7%) | 7 (14.6%) | 41 (85.4%) | 9 (18.8%) | 39 (81.3%) |
| ≥5cm | 55 (53.4%) | 19 (34.5%) | 36 (65.5%) | 5 (9.1%) | 50 (90.9%) | 5 (9.1%) | 50 (90.9%) |
| p-Value | 0.897 | 0.386 | 0.154 | ||||
| Stage (UICC) | |||||||
| I | 5 (4.9%) | 2 (40.0%) | 3 (60.0%) | 0 (0%) | 5 (100.0%) | 1 (20.0%) | 4 (80.0%) |
| II | 28 (27.2%) | 10 (35.7%) | 18 (64.3%) | 4 (14.3%) | 24 (85.7%) | 5 (17.9%) | 23 (82.1%) |
| III | 70 (67.9%) | 23 (32.9%) | 47 (67.1%) | 8 (11.4%) | 62 (88.6%) | 8 (11.4%) | 62 (88.6%) |
| p-Value | 0.924 | 0.653 | 0.642 | ||||
| Depth of tumor invasion | |||||||
| T1+T2 | 9 (8.7%) | 3 (33.3%) | 6 (66.7%) | 0 (0%) | 9 (100%) | 1 (11.1%) | 8 (88.9%) |
| T3+T4 | 94 (91.3%) | 32 (34.0%) | 62 (66.0%) | 12 (12.8%) | 82 (87.2%) | 13 (13.8%) | 81 (86.2%) |
| p-Value | 1.000 | 0.594 | 1.000 | ||||
| Lymph node metastasis | |||||||
| Negative | 32 (31.1%) | 10 (31.2%) | 22 (68.8%) | 3 (9.4%) | 29 (90.6%) | 4 (12.5%) | 28 (87.5%) |
| Positive | 71 (68.9%) | 25 (35.2%) | 46 (64.8%) | 9 (12.7%) | 62 (87.3%) | 10 (14.1%) | 61 (85.9%) |
| p-Value | 0.694 | 0.750 | 1.000 | ||||
| Histology | |||||||
| WD+MD | 86 (83.5%) | 29 (33.7%) | 57 (66.3%) | 9 (10.5%) | 77 (89.5%) | 11 (12.8%) | 75 (87.2%) |
| PD | 17 (16.5%) | 6 (35.3%) | 11 (64.7%) | 3 (17.6%) | 14 (82.4%) | 3 (17.6%) | 14 (82.4%) |
| p-Value | 0.900 | 0.413 | 0.698 | ||||
| Location | |||||||
| Colon | 67 (65%) | 22 (32.8%) | 45 (67.2%) | 7 (10.4%) | 60 (89.6%) | 8 (11.9%) | 59 (88.1%) |
| Rectum | 36 (35%) | 13 (36.1%) | 23 (63.9%) | 5 (13.9%) | 31 (86.1%) | 6 (16.7%) | 30 (83.3%) |
| p-Value | 0.738 | 0.604 | 0.505 | ||||
| Vascular invasion | |||||||
| Yes | 35 (33.9%) | 10 (28.6%) | 25 (71.4%) | 4 (11.4%) | 31 (88.6%) | 4 (11.4%) | 31 (88.6%) |
| No | 68 (66.1%) | 25 (36.8%) | 43 (63.2%) | 8 (11.8%) | 60 (88.2%) | 10 (14.7%) | 58 (85.3%) |
| p-Value | 0.406 | 1.000 | 0.768 | ||||
| Perineural invasion | |||||||
| Yes | 12 (11.7%) | 3 (25.0%) | 9 (75.0%) | 1 (8.3%) | 11 (91.7%) | 1 (8.3%) | 11 (91.7%) |
| No | 91 (88.3%) | 32 (35.2%) | 59 (64.8%) | 11 (12.1%) | 80 (87.9%) | 13 (14.3%) | 78 (85.7%) |
| p-Value | 0.747 | 1.000 | 1.000 | ||||
a
Gene expression ratio of colorectal cancer tissues (normalized with corresponding β-actin signal) compared with gene expression ratio of paired normal colorectal tumor tissues (normalized with corresponding β-actin signal). Overexpression is defined as having a fold-change ratio of >1.0. p-Value was tested by chi-square tests. p-Value <0.05 is significant.