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. 2011 Dec 27;6(12):e28851. doi: 10.1371/journal.pone.0028851

Figure 6. Hypoxia-induced RSK activation promotes invadopodia formation.

Figure 6

HT-1080 cells were cultured under normoxia (empty bars) or hypoxia (filled bars). (A) Percentage of cells producing invadopodia cultured in presence or absence of BI-D1870 (n = 3). (B) Quantification of invadopodia-associated matrix degradation was performed (n = 2). (C–D) Percentage of HT-1080 cells producing invadopodia in cells (C) transfected with DN-RSK (n = 3), or (D) transfected with NHE-1 WT or S703A (n = 3). Columns represent the mean ± SEM indicated by the horizontal bars. The asterisks correspond to, * p<0.01; ** p<0.001; *** p<0.0001.