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. 2011 Dec 27;6(12):e29166. doi: 10.1371/journal.pone.0029166

Figure 2. Impaired in vivo glucose tolerance and in vitro insulin secretion in RIP-Cre Dicer1Δ/Δ mice.

Figure 2

A. In vivo glucose tolerance test was performed on 6 control littermates and 5 RIP-Cre Dicer1Δ/Δ females at 4–5 weeks of age (left) and 6 control littermates and 6 RIP-Cre Dicer1Δ/Δ females at 13 weeks of age (right). Note that the glucose levels of the 13 weeks old RIP-Cre Dicer1Δ/Δ mice reached levels not measurable by the glucometer. Data are mean±SEM. B. Insulin secretion from isolated pancreatic islets was measured after 1 h incubation in 1 mM glucose (1 G) or 20 mM glucose (20 G) in 2 and 5–6 weeks old littermate control (white bar) or RIP-Cre Dicer1Δ/Δ mice (black bar). C. (Left) As in B, but insulin secretion was measured in 7–8 weeks old mice. (Right) Insulin release normalized to insulin content. Data are mean±SEM of 15–21 experiments in 3–5 animals. *P<0.05; ***P<0.001.