Table 4. Attempt to replicate the results of the pathway analysis in the second phase of data from the GenoMEL GWA study.

Set	SUMSTAT	SUMSQ
All genes	0.167	0.280
Anergy	0.001	0.002
Costim.	0.291	0.411
Treg	0.690	0.794
Secreted	0.738	0.783
tDC	0.701	0.761

1450 melanoma cases and 4047 controls were included in the analysis. Empirical p-values established by 1000 in-cluster (GenoMEL regional groups: Israel, Italy, France, Poland, Scandinavia, Spain, UK/Netherlands) label permutations are shown for the pathway statistics SUMSTAT and SUMSQ.