Table 1. Genetic scores based on different reference studies.
Reference studies(Authors) | Data Table# | # SNPs$ | Reference effect sizes& | ρeff * | Variance explained (%) | ||
Source | Sample size | Unweighted | Weighted | ||||
Nature 467:832-8 [11] | Suppl Table 1 | 180 | Stage 1 | 133653 | 0.455 | 5.45 | 7.79 |
Lango Allelen et al. | Stage 2 | 50074 | 0.497 | 5.45 | 7.95 | ||
Stage 1+2 | 183727 | 0.472 | 5.45 | 7.94 | |||
Females | 110489 | 0.461 | 5.45 | 7.87 | |||
Males | 73238 | 0.486 | 5.45 | 7.80 | |||
Nat Genet 40:609-15 [6] | Table 1 and 2 | 57 | Iceland | 25174 | 0.523 | 3.35 | 3.58 |
Gudbjartsson et al. | Holland | 2876 | 0.550 | 3.35 | 3.72 | ||
US Cau | 1770 | 0.448 | 2.62 | 2.69 | |||
US Afr | 1148 | 0.199 | 0.81 | 1.01 | |||
Nat Genet 40:584-91 [7] | Table 1 | 29 | Meta | 15821 | 0.492 | 3.50 | 3.48 |
Lettre et al. | Follow-up | 19990 | 0.577 | 1.43 | 3.38 | ||
Combined | 35811 | 0.539 | 3.50 | 3.85 | |||
USHT* | 2189 | 0.639 | 3.19 | 4.62 | |||
Nat Genet 40: 575-83 [8] | Table 1 | 20 | Female | na | 0.657 | 3.18 | 3.20 |
Weedon et al. | Male | na | 0.732 | 3.18 | 3.77 | ||
Eur J Hum Genet 17:1070-5 | Suppl Table 1 | 54 | Add, single | 5748 | 0.608 | 4.75 | 4.83 |
Aulchenko et al. | Genotype | 5748 | - | 4.07 | 4.28 |
The table number in the reference study, from where the list of height-associated SNPs and their effect size estimates were extracted to build the genetic scores.
The number of height-associated SNPs reported by the reference study.
Individual reference studies report multiple effect sizes estimated from multiple sources with different sample sizes. Based on these estimates, different genetic scores can be constructed.
*The Pearson correlation between the effect sizes extracted from the original report and estimated from our samples.