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. 2011 Dec 27;6(12):e29475. doi: 10.1371/journal.pone.0029475

Table 1. Genetic scores based on different reference studies.

Reference studies(Authors) Data Table# # SNPs$ Reference effect sizes& ρeff * Variance explained (%)
Source Sample size Unweighted Weighted
Nature 467:832-8 [11] Suppl Table 1 180 Stage 1 133653 0.455 5.45 7.79
Lango Allelen et al. Stage 2 50074 0.497 5.45 7.95
Stage 1+2 183727 0.472 5.45 7.94
Females 110489 0.461 5.45 7.87
Males 73238 0.486 5.45 7.80
Nat Genet 40:609-15 [6] Table 1 and 2 57 Iceland 25174 0.523 3.35 3.58
Gudbjartsson et al. Holland 2876 0.550 3.35 3.72
US Cau 1770 0.448 2.62 2.69
US Afr 1148 0.199 0.81 1.01
Nat Genet 40:584-91 [7] Table 1 29 Meta 15821 0.492 3.50 3.48
Lettre et al. Follow-up 19990 0.577 1.43 3.38
Combined 35811 0.539 3.50 3.85
USHT* 2189 0.639 3.19 4.62
Nat Genet 40: 575-83 [8] Table 1 20 Female na 0.657 3.18 3.20
Weedon et al. Male na 0.732 3.18 3.77
Eur J Hum Genet 17:1070-5 Suppl Table 1 54 Add, single 5748 0.608 4.75 4.83
Aulchenko et al. Genotype 5748 - 4.07 4.28
#

The table number in the reference study, from where the list of height-associated SNPs and their effect size estimates were extracted to build the genetic scores.

$

The number of height-associated SNPs reported by the reference study.

&

Individual reference studies report multiple effect sizes estimated from multiple sources with different sample sizes. Based on these estimates, different genetic scores can be constructed.

*The Pearson correlation between the effect sizes extracted from the original report and estimated from our samples.