Table 2. Nine replicated height-associated loci identified by GC approach.
| No | Regions# | Index SNPs$ | GWAS SNPs& | Genes | |||||
| chr | start | end | length | rs_id | MAF | P-value | |||
| 1 * | 2 | 55822780 | 56080130 | 257351 | rs6730839 | 0.25 | 1.53×10−6 | rs3791679 | EFEMP1 |
| rs3791675 | |||||||||
| 2 * | 20 | 33267822 | 34124695 | 856874 | rs6058227 | 0.13 | 8.21×10−6 | rs6060369 | UQCC |
| rs6088813 | |||||||||
| rs6060373 | |||||||||
| rs2236164 | |||||||||
| rs6088792 | |||||||||
| 3 | 5 | 152756659 | 153018678 | 262020 | rs7737904 | 0.03 | 2.12×10−5 | rs12658202 | GRIA1 |
| 4 * | 12 | 64588210 | 64702663 | 114454 | rs1042725 | 0.49 | 5.21×10−5 | rs8756 | HMGA2 |
| rs1042725 | |||||||||
| 5 | 6 | 130271009 | 130327351 | 56343 | rs10457532 | 0.24 | 1.22×10−4 | rs6899976 | L3MBTL3 |
| rs6569648 | |||||||||
| 6 | 12 | 92723646 | 92899954 | 176309 | rs10444517 | 0.06 | 1.24×10−4 | rs11107116 | CRADD |
| rs3825199 | |||||||||
| 7 | 3 | 135631761 | 135778576 | 146816 | rs9866359 | 0.14 | 1.44×10−4 | rs10935120 | ANAPC13 |
| 8 | 7 | 28128599 | 28246163 | 117565 | rs849315 | 0.12 | 1.62×10−4 | rs1635852 | JAZF1 |
| rs849141 | |||||||||
| 9 | 12 | 101541161 | 101630322 | 89162 | rs833718 | 0.50 | 1.94×10−4 | rs5742692 | IGF1 |
| rs1520223 | |||||||||
#
Each significant region was selected starting with a “seed” SNP (P<5×10−4) and was extended to adjacent SNPs with (P<5×10−3) within 25 kb. The chromosomal positions were based on NCBI Genome Build 36.3.
$
Index SNPs were the most significant SNP observed in each region.
&
GWAS SNPs were known height-associated SNPs within or near (<250 kb) the region (extracted from GWA catalog: http://www.genome.gov/gwastudies/).
*These three regions were also in the top 100 regions identified by MG approach.