Table 4. Estimation of haplotype frequencies in the UCPs SNPs and association with longevity in the analyzed sample.

Gene	SNPs			Freqa	Score	P-valueb
UCP2-UCP3	rs660339	rs659366	rs15763
	C	A	C	0.029	−2.876	0.003
	C	G	C	0.596	−1.747	0.086
	C	G	T	0.028	0.317	0.754
	C	A	T	0.004	0.877	0.400
	T	A	C	0.077	0.953	0.347
	T	G	C	0.050	0.971	0.339
	T	A	T	0.184	1.390	0.165
	T	G	T	0.030	1.985	0.046

^aEstimated haplotype frequency.

^bMonte-Carlo p-value from 10⁴ replications.

Note: p-values of global score statistics based on 10⁴ replications were 0.047 for UCP2-UCP3 haplotypes, 0.0028 for UCP3 haplotypes.