Table III.

The Comparisons of Adjusted Means in Syndromic Groups with Controls

Pyridinium Crosslink	Control	Noonan Syndrome			CFC Syndrome			Costello Syndrome
	LS Mean3 ± SE3	LS Mean3 ± SE3	Diff.3 ±SE	p-value1	LS Mean3± SE3	Diff.3 ±SE	p-value1	LS Mean3 ± SE3	Diff.3 ±SE	p-value1
Pyd2 (umol/molcrt)	197.30 ± 8.38	282.42 ± 22.08	85.12 ± 23.83	0.0005	232.12 ± 21.86	34.82 ±23.44	0.1397	242.62 ± 18.60	45.32 ± 20.82	0.0311
Dpd2 (umol/molcrt)	42.84 ± 2.8	77.86 ± 5.48	35.03 ± 5.92	<0.0001	71.01 ± 5.43	28.17 ±5.82	<0.0001	68.99 ± 4.62	26.16 ± 5.17	<0.0001
Dpd/Pyd ratio	0.22 ± 0.004	0.28 ± 0.01	0.057 ± 0.013	<0.0001	0.30 ± 0.01	0.080 ± 0.013	<0.0001	0.29 ± 0.01	0.070 ±0.011	<0.0001

Note:

¹Comparison with control

²Pyd=pyridinoline; Dpd=deoxypyridinoline; crt=creatinine

³LS=least square, SE=standard error of LS mean, Diff. =difference