Figure 5.
(A) AKBA inhibits the expression of COX-2, cyclin D1, MMP-9, and VEGF in CRC tissues from mice. Percentages indicate positive staining for the given biomarker. Samples from three animals in each group were analyzed, and representative data are shown. V, vehicle; L, low (AKBA 50 mg/kg); M, medium (100 mg/kg); and H, high (200 mg/kg). (B) Schematic representation of mechanism by which AKBA inhibited growth/ Metastasis of orthotopically implanted CRC.