Figure 1. DMP1-SOST mice exhibit less resistance to mechanical loading.
A. Ex vivo strain measurements were performed at the medial surface of the ulnar midshaft from WT and TG mice. TG mice exhibited greater deformation per unit force than their WT counterparts. Bars represent means ± SD, n=6. * indicates p<0.05 versus WT mice by Student’s t-Test. B. Linear relation between applied peak force and mechanical strain in the midshaft ulna from WT and TG mice. C. Loading forces applied to achieve equivalent low, medium, and high magnitude of strain in WT and TG ulnae are shown.