Table VIII.

Particle Size at Different Time Interval of Dispersion Test of Danazol at Different Ratios of Lipid: Surfactant and Mixture of Lipids: Surfactant (n = 3)

Time (min)	Particle size (nm) ± s.d.
	1:1 (Lipid: Surfactant)		3:7 (Lipid:Surafactant)
	Control	With drug	Control	With drug
Capmul MCM a
10	434 ± 19	424 ± 17	420 ± 19	430 ± 12
15	471 ± 17	440 ± 19	492 ± 12	500 ± 15
30	517 ± 20	486 ± 20	556 ± 13	557 ± 15
60	493 ± 12	487 ± 16	499 ± 12	563 ± 16
120	506 ± 13	522 ± 11	496 ± 14	565 ± 13
Glycerol dicaprylate
10	94 ± 4	92 ± 5	80 ± 5	69 ± 3
15	104 ± 5	107 ± 3	80 ± 4	68 ± 2
30	113 ± 2	115 ± 2	67 ± 5	69 ± 1
60	114 ± 3	119 ± 3	69 ± 5	56 ± 1
120	113 ± 2	116 ± 1	61 ± 2	66 ± 3
Captex 8000 b
10	123 ± 3	125 ± 3	30 ± 1	29 ± 3
15	161 ± 2	156 ± 5	29 ± 1	27 ± 3
30	179 ± 4	173 ± 4	29 ± 1	26 ± 2
60	183 ± 5	176 ± 2	28 ± 1	26 ± 1
120	175 ± 4	176 ± 3	27 ± 2	25 ± 1
Captex 355 c
10	159 ± 3	127 ± 5	28 ± 2	29 ± 1
15	197 ± 5	168 ± 4	27 ± 3	28 ± 1
30	217 ± 4	196 ± 3	28 ± 1	23 ± 3
60	225 ± 3	199 ± 5	26 ± 3	28 ± 1
120	216 ± 2	200 ± 2	25 ± 3	28 ± 1
Capmul MCM :Glyceryl dicaprylate (1:1)
10	62 ± 3	41 ± 1	325 ± 20	236 ± 24
15	59 ± 2	40 ± 3	372 ± 24	253 ± 18
30	57 ± 4	40 ± 2	363 ± 19	379 ± 20
60	50 ± 1	38 ± 2	377 ± 20	469 ± 19
120	67 ± 2	40 ± 3	404 ± 25	451 ± 21
Capmul MCM : Captex 355 (1:3)
10	31 ± 3	31 ± 3	21 ± 1	21 ± 2
15	40 ± 1	32 ± 1	24 ± 2	21 ± 1
30	49 ± 3	39 ± 4	21 ± 3	21 ± 2
60	36 ± 2	36 ± 1	23 ± 1	21 ± 3
120	36 ± 1	34 ± 1	21 ± 1	22 ± 1
Capmul MCM : Captex 355 (1:1)
10	28 ± 1	25 ± 2	19 ± 1	21 ± 1
15	27 ± 2	28 ± 1	20 ± 2	22 ± 1
30	32 ± 1	29 ± 2	20 ± 3	23 ± 2
60	29 ± 3	28 ± 2	19 ± 2	22 ± 2
120	29 ± 1	28 ± 1	20 ± 1	24 ± 1
Capmul MCM : Captex 355 (3:1)
10	266 ± 10	325 ± 11	47 ± 1	49 ± 2
15	299 ± 9	324 ± 7	54 ± 2	51 ± 1
30	291 ± 8	426 ± 7	69 ± 1	67 ± 3
60	323 ± 7	421 ± 5	66 ± 2	44 ± 3
120	287 ± 5	320 ± 5	60 ± 2	40 ± 2

^aCapmul MCM - Glycerol monocaprylocaprate

^bCaptex 8000 - Glycerol tricaprylate

^cCaptex 355 - Caprylic/capric triglyceride