Table II.
Characteristics of Octreotide-Loaded Microspheres (n = 3) Prepared Using PLHMGAs of Different Composition and the Commercial PLGA Formulation (Sandostatin LAR®)
| Polymer | Copolymer composition | Volume weight mean diameter (μm) | LEa (%) | LCb (%) |
|---|---|---|---|---|
| Poly(D,L-lactide-co-hydroxymethyl glycolide) | 75/25 | 11.6 ± 2.2 | 57.8 ± 3.5 | 3.2 ± 0.2 |
| 65/35 | 15.6 ± 0.6 | 57.1 ± 2.6 | 3.5 ± 0.2 | |
| 50/50 | 12.6 ± 1.5 | 67.1 ± 0.3 | 3.9 ± 0.0 | |
| cPLGA (Sandostatin LAR®) | 50/50 | 65.0 | dN.A. | 4.1 ± 0.1 |
a LE Loading efficiency
b LC Loading capacity
cThe results are from one single batch; LC was determined in triplicate
d NA data not available