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. 2011 Jul 9;29(1):110–120. doi: 10.1007/s11095-011-0517-3

Table II.

Characteristics of Octreotide-Loaded Microspheres (n = 3) Prepared Using PLHMGAs of Different Composition and the Commercial PLGA Formulation (Sandostatin LAR®)

Polymer Copolymer composition Volume weight mean diameter (μm) LEa (%) LCb (%)
Poly(D,L-lactide-co-hydroxymethyl glycolide) 75/25 11.6 ± 2.2 57.8 ± 3.5 3.2 ± 0.2
65/35 15.6 ± 0.6 57.1 ± 2.6 3.5 ± 0.2
50/50 12.6 ± 1.5 67.1 ± 0.3 3.9 ± 0.0
cPLGA (Sandostatin LAR®) 50/50 65.0 dN.A. 4.1 ± 0.1

a LE Loading efficiency

b LC Loading capacity

cThe results are from one single batch; LC was determined in triplicate

d NA data not available