Skip to main content
. 2012 Jan;19(1):9–14. doi: 10.1101/lm.024042.111

Figure 2.

Figure 2.

Inhibition of Myosin II ATPase activity in the lateral amygdala blocks the formation, but not expression, of long-term fear memory. (A) Schematic of experimental design for LTM test. (B) Intra-LA infusions of the Myosin II ATPase inhibitor, blebb, prior to cued fear conditioning blocks memory formation (F(1,10) = 26.90; n = 5, inactive; n = 6, active blebb; * denotes significantly different LTM at 24 h, P ≤ 0.001). (C) Location of needle tips for all intra-LA infusions. Diagram represents histology from animals whose behavioral data are depicted in B. (D) Schematic of experimental design for memory expression test. (E) Infusions of blebb into the LA 30 min prior to a LTM test have no effect on memory expression (F(1,10) = 0.15, P > 0.05; n = 5, inactive; n = 6, active blebb). (F) Location of needle tips for all intra-LA infusions given to animals whose behavioral data are depicted in E. Because of the extensive overlap of the infusion needle tips between animals, not all tip locations are resolvable on the diagrams. Error bars represent SEM.