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Phenotypic variability simulated by varying in silico genes that each determine one model parameter. Red is the baseline genotype. (A) Action potential and (B) calcium transient under regular pacing at 100 ms intervals. Only genotypes for which dynamics converged without alternans are shown (about 56% of 310 = 59049 cases). (C,D) Fast sodium current under a double-pulse voltage-clamp experiment. Note that the time axes are truncated.
