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. 2012 Jan;135(1):89–99. doi: 10.1111/j.1365-2567.2011.03516.x

Figure 2.

Figure 2

Anti-GII-4 IgG response. BALB/c mice were immunized intradermally (ID) or intramuscularly (IM) twice with 10 μg of norovirus (NoV) GII-4 virus-like particles (VLPs), GII-4 P-particles, or no immunogen (naive). (a) Termination sera were tested in ELISA at 1 : 200 dilutions. The values shown are the optical density (OD) values of each individual serum and the mean OD of the group (horizontal bar). Groups were compared by Mann–Whitney U-test; *P=0.016, **P=0.009. (b) Kinetics of norovirus GII-4-specific serum IgG response. Serum samples collected at study weeks 0, 2, 3, 4 and 5 were tested for GII-4-specific IgGs in ELISA at 1 : 200 dilutions. Mean OD values of the groups with standard errors are shown. Immunizations at week 0 and week 3 are indicated with arrows. (c) Mean avidity indices (%) of norovirus GII-4-specific serum IgG antibodies. Termination sera are tested at the dilution of 1 : 200. Bars show the mean avidity index of an experimental group.