Table 1.

The SLC36 family of mammalian amino acid transporters

Gene*	Protein	Aliases	Examples of natural substrates, drugs and related derivatives
SLC36A1	PAT1	imino acid carrier	Small, unbranched, zwitterionic α-, β- and γ-amino and imino acids; N-methylated amino acids; heterocyclic amino acids containing four- to six-membered rings. Substrates include glycine, proline, alanine, trans-4-hydroxy-proline, β-alanine, taurine, sarcosine, betaine, GABA, d-proline, d-alanine, d-cysteine, d-serine, MeAIB, AIB, β-ABA, nipecotic acid, guvacine, THPO, isonipecotic acid, muscimol, gaboxadol, vigabatrin, 1-aminocyclopropanecarboxylic acid, 3-amino-1-propanesulphonic acid, l-azetidine-2-carboxylic acid, 3,4-dehydro-d,l-proline, l- and d-cycloserine, 5-aminolevulinic acid, β-guanidinopropionic acid, and short-chain fatty acids (butyrate, acetate, propionate).
		LYAAT-1
		Tramdorin 3
SLC36A2	PAT2	Tramdorin 1	Small, unbranched, dipolar amino and imino acids and heterocyclic amino acids containing four- to five-membered rings. Substrates include glycine, alanine, l- and d-proline, trans-4-hydroxy-proline, sarcosine, MeAIB, d- and l-cycloserine, l-azetidine-2-carboxylic acid, 3,4-dehydro-d,l-proline, and short-chain fatty acids (acetate, propionate, butyrate).
SLC36A3	PAT3	Tramdorin 2
SLC36A4	PAT4	LYAAT-2	Proline, tryptophan

^*The full list of SLC tables can be found at the HUGO Gene Nomenclature Committee (HGNC) Database at: http://www.bioparadigms.org/slc/intro.htm