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. 2011 Dec;164(7):1829–1844. doi: 10.1111/j.1476-5381.2011.01475.x

Figure 2.

Figure 2

Recovery of B-cells after morphine treatment is due to proliferation of B-cell precursors. Mice were treated with morphine or placebo for 7, 14 or 21 days. Untreated control mice are shown as a dashed line. (A) The absolute numbers of splenic B-cells are shown. (B) The percentage of splenic B-cells in the S, G2 or M phase of the cell cycle are shown. (C) Bone marrow cells were analysed for B220 and IgM expression and the percentages of cells in each gate are shown. (D) Cells were gated as in (C) and analysed for DNA content. The percentages of cells in each gate that were in the S, G2 or M phase of the cell cycle are shown. *P < 0.05, **P < 0.01, comparing morphine-treated mice and placebo-treated mice.