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Morphine pellet implantation leads to sustained serum morphine levels and a transient increase in serum corticosterone levels. Mice were implanted with pellets containing morphine (M), morphine and naltrexone (M + N), naltrexone (N), or placebo (P) and blood was collected at the indicated time points. The concentrations of morphine (A) and corticosterone (B) in sera of mice treated for the indicated lengths of time are shown. Untreated control mice (C) were also analysed (B).
