Table 1.
Spleen, lymph node, bone marrow and thymus cell numbers in morphine-treated and control groups
| Morphine (n = 13) | Morphine + naltrexone (n = 7) | Naltrexone (n = 7) | Placebo (n = 7) | |
|---|---|---|---|---|
| Spleen | ||||
| B cells | 6.9 ± 7.2 | 14 ± 7.7 | 14 ± 7.2* | 18 ± 15* |
| CD4+ cells | 2.3 ± 1.1 | 6.1 ± 1.8* | 6.2 ± 2.0* | 6.0 ± 3.5* |
| CD8+ cells | 2.1 ± 0.91 | 3.9 ± 0.85* | 3.8 ± 1.1* | 5.7 ± 4.3* |
| Lymph nodes | ||||
| B cells | 1.2 ± 0.96 | 7.5 ± 3.1 | 2.7 ± 1.4 | 2.4 ± 1.5* |
| CD4+ cells | 0.95 ± 0.50 | 3.1 ± 1.3* | 2.4 ± 0.44* | 2.8 ± 0.46* |
| CD8+ cells | 0.90 ± 0.49 | 2.0 ± 1.3 | 1.2 ± 0.46 | 3.1 ± 2.7* |
| Bone marrow | 14 ± 3.2 | 15 ± 1.1 | 14 ± 2.2 | 15 ± 2.9 |
| Thymus | 2.6 ± 2.2 | 32 ± 9.3* | 41 ± 25* | 46 ± 29* |
Data shown are the absolute numbers of cells (×106) in the indicated tissues (mean ± SD) in morphine-treated, morphine + naltrexone-treated, naltrexone-treated and placebo-treated mice.
*
P < 0.05, significantly different from the morphine-treated group.