Table II.
Effects of dietary lyophilized strawberries and black raspberries on NMBA-induced DNA adduct formation in the rat esophagus
| Treatment | pmol O6-meGua/mg DNA | % Inhibition |
| NMBA (0.25 mg/kg) | 4.4 ± 0.9 | — |
| NMBA + 5% STRWs | 1.4 ± 0.1a | 68 |
| NMBA + 10% STRWs | 1.9 ± 0.7a | 57 |
| NMBA + 5% BRs | 1.2 ± 0.3a | 73 |
| NMBA + 10% BRs | 0.9 ± 0.2a | 80 |
STRWs, strawberries; BRs, black raspberries; O6-meGua, O6-methylguanine. Rats were fed 5 or 10% lyophilized STRWs or BRs for 14 days and then given a single subcutaneous injection of NMBA at 0.25 mg/kg body wt. The esophageal DNA was isolated and O6-meGua measured. STRW data are taken from Carlton et al. (38) and BR data are from Kresty et al. (25).
a
Significantly different from NMBA controls (P < 0.05).