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. 2011 Nov 3;10:135. doi: 10.1186/1476-4598-10-135

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Copyright ©2011 Yamamoto et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Akt3, whose expression was inversely correlated with miR-505, is associated with drug resistance in MCF7-ADR cells. (A) Scatter plot of 2 probes of Akt3 genes that up-regulated in MCF7-ADR cells. (B) Real-time RT-PCR analysis for Akt3 in miR-505 or control miRNA-transfected cells. Seventy-two hours after transfection with miR-505 or control miRNA, Akt3 expression levels were determined. Expression levels were normalized to GAPDH expression levels. N = 9, mean ± S.D. is shown. (C) Down-regulation of Akt3 induced cell growth arrest in MCF7-ADR cells at 1, 10 and 20 nM DOC conditions. Cell growth was calculated by luciferase activity. n = 3, ∗, P < 0.05. ∗∗, 0.01.