Table 4.

Pure-tone air conduction threshold average^* at baseline and change over time (per-protocol populations)

	Artemether-lumefantrine	Atovaquone-proguanil	Artesunate-mefloquine
Baseline	N = 148	N = 51	N = 47
Right ear	12.2 [11.4, 13.0]	12.0 [10.5, 13.6]	12.7 [11.2, 14.2]
Left ear	11.4 [10.5, 12.3]	11.3 [9.9, 12.7]	12.5 [10.8, 14.3]
Day 3	N = 145	N = 50	N = 45
Right ear	−2.5 [−3.1, −1.9]	−2.4 [−3.6, −1.2]	−1.9 [−3.0, −0.7]
Left ear	−1.2 [−1.8, −0.5]	−1.5 [−2.6, −0.3]	−1.2 [−2.2, −0.1]
Day 7	N = 143	N = 49	N = 46
Right ear	−2.2 [−2.9, −1.5]	−2.6 [−4.0,−1.1]	−2.6 [−3.9, −1.3]
Left ear	−1.7 [−2.4, −0.9]	−1.3 [−2.8, 0.2]	−1.4 [−2.8, −0.1]
Day 28	N = 143	N = 50	N = 46
Right ear	−2.7 [−3.5, −1.9]	−2.6 [−4.2, −1.0]	−3.6 [−4.8, −2.3]
Left ear	−2.0 [−2.8, −1.1]	−1.8 [−3.0, −0.5]	−2.5 [−4.3, −0.7]
Day 42	N = 138	N = 49	N = 47
Right ear	−3.0 [−3.8, −2.2]	−3.3 [−4.9, −1.7]	−3.1 [−4.2, −1.9]
Left ear	−1.5 [−2.7, −0.4]	−2.1 [−3.5, −0.6]	−3.0 [−4.7, −1.3]

^*Average of the pure-tone thresholds for the frequencies 500, 1000, 2000, and 3000 Hz.

Data are presented as mean change from baseline (dB) [95% CI]; none of the average changes exceed the measurement error for pure-tone thresholds.

CI = confidence interval; N = number of patients in the respective per-protocol population.