Table 6.
Change from baseline in hematology parameters over time (safety population)*
| Day 3 | Day 7 | Day 28 | Day 42 | |
|---|---|---|---|---|
| Hemoglobin (g/L) | ||||
| A-L (N = 157–159) | −5.9 ± 10.2 | −6.3 ± 11.5 | 0.6 ± 14.8 | 3.7 ± 16.1 |
| A-P (N = 52–53) | −8.0 ± 10.5 | −8.9 ± 12.6 | 0.6 ± 15.9 | 1.8 ± 19.1 |
| A-M (N = 52–53) | −4.8 ± 8.8 | −5.1 ± 10.7 | 3.4 ± 12.7 | 3.9 ± 13.7 |
| Hematocrit (%) | ||||
| A-L (N = 157–159) | −1.9 ± 3.4 | −2.0 ± 3.7 | −0.3 ± 5.0 | 0.7 ± 5.1 |
| A-P (N = 51–53) | −2.4 ± 2.6 | −3.2 ± 3.4 | −0.4 ± 5.2 | 0.5 ± 6.1 |
| A-M (N = 52–53) | −1.0 ± 2.9 | −0.8 ± 3.7 | 1.6 ± 4.4 | 2.0 ± 4.5 |
| WBC (total) (109/L) | ||||
| A-L (N = 157–159) | −0.3 ± 2.3 | 1.5 ± 2.6 | 1.5 ± 2.7 | 1.5 ± 3.2 |
| A-P (N = 52–53) | −0.3 ± 1.8 | 2.4 ± 2.8 | 2.2 ± 2.4 | 2.5 ± 2.9 |
| A-M (N = 52–53) | 0.1 ± 2.4 | 2.6 ± 2.6 | 1.6 ± 2.9 | 2.1 ± 3.2 |
*
All values are presented as mean ± standard deviation.
A-L = artemether-lumefantrine; A-P = atovaquone-proguanil; A-M = artesunate plus mefloquine; N = number of patients with assessments; WBC = white blood cells.