Table 8.
Polymerase chain reaction-corrected cure rates by body mass index and body weight on day 42 (full analysis set)*
| Artemether-lumefantrine | Atovaquone-proguanil | Artesunate-mefloquine | |
|---|---|---|---|
| BMI < 25 kg/m2 | N = 109 | N = 42 | N = 32 |
| 106 (97.2) | 40 (97.6)† | 32 (100) | |
| [92.2–99.4] | [87.1–99.9] | [89.1–100] | |
| BMI ≥ 25 kg/m2 | N = 50 | N = 11 | N = 21 |
| 49 (98.0) | 11 (100) | 20 (95.2) | |
| [89.4–99.9] | [71.5–100] | [76.2–99.9] | |
| Weight < 70 kg | N = 109 | N = 35 | N = 34 |
| 106 (97.2) | 33 (97.1)‡ | 34 (100) | |
| [92.2–99.4] | [84.7–99.9] | [89.7–100] | |
| Weight ≥ 70 kg | N = 50 | N = 18 | N = 19 |
| 49 (98.0) | 18 (100) | 18 (94.7) | |
| [89.4–99.9] | [81.5–100] | [74.0–99.9] |
Data are presented as n (%) [95% CI]. Exact Pearson-Clopper limits.
BMI = body mass index; CI = confidence interval
N = 41.
N = 34.