Table 4.

Performance of the prediction of NMA-derived B-factors (BNMA) from PSSM, the observed and predicted values and their combination of the equilibrium structural features (ESFs).

Input features	Prediction performance (Correlation with BNMA)	Prediction performance (Correlation with randomized BNMA)	P-value
PSSM (9 residue window) and amino acid composition	0.21	-0.02	1.3e-7
ESFs (Observed)	0.52	0.00	< 2.2e-16
ESFs (Predicted)	0.23	-0.01	4.1e-10
ESFs (Predicted + Observed)	0.46	-0.01	< 2.2e-16

Performance on randomized BNMA is shown for reference and a p-value is calculated using Welsh's t-test on the two sets of protein-wise performance scores (correlation coefficients). The predicted ESFs alone can predict BNMA with reasonable performance.