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. 2011 Oct 28;5:178. doi: 10.1186/1752-0509-5-178

Table 4.

Modeled reactions and rates of basal cyclic nucleotide signaling.

Reaction	Rate
Basal AC influx of cAMP (r1):	υ₁= k₁₁;
Basal GC influx of cGMP (r2):	Υ₂= k₁₂;
cAMP turnover via PDE2 (r3):	$υ_{3} = k_{1} \cdot {x_{1}}^{k_{19}} \cdot x_{3} / (k_{2} + {x_{1}}^{k_{19}});$
cAMP turnover via PDE3 (r4):	υ₄= k₃·x₄·x₁/(k₄+x₁);
cGMP turnover via PDE2 (r5):	υ₅= k₅·x₃·x₂/(k₆+x₂);
cGMP turnover via PDE3 (r6):	υ₆= k₇·x₄·x₂/(k₈+x₂);
cGMP turnover via PDE5 (r7):	υ₇= k₉·x₅·x₂/(k₁₀+x₂);
(De)activation of PDE (r8- r13):	υ₈= k₁₄·x₆;
	υ₉= k₁₃·x₃;
	υ₁₀= k₁₆·x₇;
	υ₁₁= k₁₅·x₄;
	υ₁₂= k₁₈·x₈;
	υ₁₃= k₁₇·x₅;

Itemized modeled reactions r and rates υ describing the basal cyclic nucleotide signaling (see Appendix).