Figure 1.

Chemical structures of nucleoside and dendrimer derivatives. MRS5221 5 is a 5'-N-methyl-carboxamido adenosine analogue with a (N)-methanocarba ring system that served as a synthetic precursor for the conjugation to an azide-functionalized G4 PAMAM dendrimer 4b to synthesize the GLiDe conjugate MRS5246 6. The monomer, MRS5233 3 contained a 2-alkynyl chain similar to MRS5221, but also contains a triazole linker group present in the PAMAM conjugate 6. MRS5401 4a is a closely related unliganded PAMAM precursor molecule.