Table 1.

OAR dose constraints used for planning for the phase I trial

Critical Structure Dose Limits
Serial Tissue	Volume	Volume Max (Gy)	Max Point Dose (Gy)	Endpoint (≥ Grade 3)
Spinal Cord and medulla	< 0.35 cc	10 Gy	14 Gy	myelitis
	< 1.2 cc	7 Gy
Spinal Cord Subvolume (5-6 mm above and below level treated)	< 10% of subvolume	10 Gy	14 Gy	myelitis
Skin	< 10 cc	23 Gy	26 Gy	ulceration
Stomach	< 10 cc	11.2 Gy	12.4 Gy	ulceration/fistula
Duodenum*	< 5 cc < 10 cc	11.2 Gy 9 Gy	12.4 Gy	ulceration
Jejunum/Ileum*	< 5 cc	11.9 Gy	15.4 Gy	enteritis/obstruction
Colon*	< 20 cc	14.3 Gy	18.4 Gy	colitis/fistula
Liver	700 cc	9.1 Gy		Basic Liver Function
Renal cortex (Right & Left)	200 cc	8.4 Gy		Basic renal function