Table 3. Key genes (Degree≥5) of Signal-Net.

Gene	Gene product	Expression	Betweenness centralitya	Degree	Inb	Outc
Mapk3	mitogen-activated protein kinase 3	down	2.28E–02	12	8	6
Traf6	TNF receptor-associated factor 6	up	7.62E–03	9	2	8
Ptpn6	protein tyrosine phosphatase, non-receptor type 6	down	0	8	0	8
Jak1	Janus kinase 1	up	9.90E–04	8	7	1
Calm2	calmodulin 2	down	9.50E–03	7	6	5
Chuk	conserved helix-loop-helix ubiquitous kinase	up	1.88E–03	6	4	2
Itgb2	integrin beta 2	up	1.98E–04	5	4	2
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	down	1.11E–02	5	4	1
Pip5k1c	phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma	up	1.39E–03	5	3	5
Irf7	interferon regulatory factor 7	down	2.57E–03	5	5	2

^aBetweenness Centrality represents the gene's mediate ability, and Degree represents the number of gene–gene interactions.

^b,cIn and out (Indegree and Outdegree) represent the gene regulation numbers upstream and downstream.