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. 2011 Dec 28;6(12):e29428. doi: 10.1371/journal.pone.0029428

Figure 1. Pfs25 specific total IgG responses following Ad-MVA Pfs25 and ChAd63 Pfs25 immunization.

Figure 1

(A) BALB/c mice were immunized with Ad-MVA Pfs25 (AdHu5 Pfs25 prime, MVA Pfs25 boost). Total IgG responses against recombinant Pfs25 protein were measured by ELISA in the serum of mice taken at the number of weeks following first immunization as shown. Mean ELISA titers ± sem (n = 10) are shown. Titers increased over time following the first immunization and were boosted following MVA Pfs25 administration at week 10 (arrow). The dotted line represents the titer required to provide 50% efficacy against P. falciparum in a SMFA using alternative vaccine platforms, according to previously published methods. (B) BALB/c mice were immunized with ChAd63 Pfs25 (n = 25) or AdHu5 Pfs25 (n = 10). Total IgG responses against recombinant Pfs25 protein were measured by ELISA in the serum of mice taken 8 weeks following a single immunization. Geomean ELISA titers ±95% CI are shown.