Table 1.
Significant Canonical Pathways from IPA library associated with differentially expressed gene set in High PCB exposure.
| Ingenuity Canonical Pathways | −log(p-value) | Ratio | Molecules |
|---|---|---|---|
| Atherosclerosis Signaling | 3.32E00 | 4.72E-02 | CSF1, CXCR4, IL1F7, PRDX6, TNFRSF12A |
| Macropinocytosis Signaling | 3.06E00 | 5.56E-02 | ITGB1, CSF1, PIK3R5, ITGB4 |
| Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis | 2.57E00 | 2.78E-02 | ITGB1, CSF1, RUNX2, PIK3R5, IL1F7, BCL2 |
| Aminosugars Metabolism | 2.05E00 | 4.69E-02 | PDE8A, GM2A, HEXB |
| Glycosphingolipid Biosynthesis - Globoseries | 1.92E00 | 8E-02 | GM2A, HEXB |
| N-Glycan Degradation | 1.8E00 | 6.9E-02 | GM2A, HEXB |
| HER-2 Signaling in Breast Cancer | 1.88E00 | 3.85E-02 | ITGB1, PIK3R5, ITGB4 |
| Reelin Signaling in Neurons | 1.86E00 | 3.85E-02 | ITGB1, BLK, PIK3R5 |
| Altered T Cell and B Cell Signaling in Rheumatoid Arthritis | 1.82E00 | 3.66E-02 | CSF1, IL1F7, IL23A |
| Melanocyte Development and Pigmentation Signaling | 1.77E00 | 3.57E-02 | SOX10, PIK3R5, BCL2 |
| Glycosphingolipid Biosynthesis - Ganglioseries | 1.74E00 | 6.45E-02 | GM2A, HEXB |
| Dendritic Cell Maturation | 1.73E00 | 2.52E-02 | PIK3R5, IGHG1, IL1F7, IL23A |
| Virus Entry via Endocytic Pathways | 1.72E00 | 3.41E-02 | ITGB1, PIK3R5, ITGB4 |
| PTEN Signaling | 1.66E00 | 3E-02 | ITGB1, PIK3R5, BCL2 |
| Glycosaminoglycan Degradation | 1.62E00 | 5.56E-02 | GM2A, HEXB |
| Glioma Signaling | 1.59E00 | 2.8E-02 | E2F5, CAMK1G, PIK3R5 |
| Docosahexaenoic Acid (DHA) Signaling | 1.58E00 | 5E-02 | PIK3R5, BCL2 |
| Pancreatic Adenocarcinoma Signaling | 1.51E00 | 2.7E-02 | E2F5, PIK3R5, BCL2 |
| Leukocyte Extravasation Signaling | 1.48E00 | 2.17E-02 | ITGB1, ARHGAP6, CXCR4, PIK3R5 |
| Integrin Signaling | 1.44E00 | 2.04E-02 | ITGB1, PIK3R5, ITGB4, TTN |
| Role of Cytokines in Mediating Communication between Immune Cells | 1.33E00 | 3.85E-02 | IL1F7, IL23A |
| Role of BRCA1 in DNA Damage Response | 1.27E00 | 3.45E-02 | ATF1, E2F5 |