. Author manuscript; available in PMC: 2013 Mar 15.

Published in final edited form as: Int J Cancer. 2011 Aug 3;130(6):1338–1346. doi: 10.1002/ijc.26162

Table 3.

Association of significant SNPs with square-root total NNAL

Gene	SNP	All subjects			Controls only			Case genotype counts^b	Control genotype counts ^b	Case minor allele frequency	Control minor allele frequency

		Estimate (95%CI)^a	p-value	fdr q- value	Estimate (95%CI)^a	p- value	fdr q- value
HSD11B1	rs2235543	−0.38 (−0.52, −0.27)	1.37E-07	1.07E-05	−0.38 (−0.59, −0.16)	0.0013	0.10	2/5/28	1/8/43	0.13	0.10
HSD11B1	rs3753519	−0.42 (−0.68, −0.16)	0.0017	0.07	−0.42 (−0.73, −0.12)	0.0076	0.31	2/5/28	0/7/45	0.13	0.07
AKR1C4	rs7083869	−0.21 (−0.38, −0.04)	0.019	0.51	−0.21 (−0.43, 0.013)	0.06	0.99	2/14/19	0/19/33	0.26	0.18
HSD11B1	rs10863782	−0.26 (−0.51, −0.02)	0.035	0.72	−0.26 (−0.52, −0.01)	0.039	0.99	2/7/26	0/12/40	0.16	0.12

additive genetic model, controlling for age, sex, square-root packyears, square-root nicotine

homozygous variant/heterozygous/homozygous wild type