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. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: Circ Arrhythm Electrophysiol. 2011 Oct 9;4(6):926–935. doi: 10.1161/CIRCEP.111.964643

Figure 3.

Figure 3

Nucleotide sensitivities of CCS and ventricular KATP channels. A) Representative traces of the mean patch current (patches contained many active channels). ATP (1 µmol/L to 1 mmol/L) was applied until steady state block occurred. B): Current (normalized to the maximal channel current in the absence of ATP; Io) is plotted as a function of the ATP concentration. Shown are mean±SEM of cumulative data (n=12 for CCS and ventricle). C) Representative experimental recordings demonstrating the effect of MgADP on KATP channels. D) The degree of activation was normalized as (I-I½)/(Io-I½), with I is the mean patch current, I½ the current recorded in the presence of 50 or 100 µM ATP, and Io the current measured in the absence of nucleotides (n=13 for CCS and n=12 for ventricle). The solid lines were produced by a KATP channel numerical model (see Supplemental Information). The dashed lines represent zero current.