Pharmacological profiles of CCS and ventricular KATP channels recorded in the inside-out patch clamp configuration. A) Representative recordings of a CCS or ventricular KATP channel demonstrating the effects of diazoxide (Diaz, 200 µM), diazoxide plus tolbultamide (Tolb, 200µM), levcromakalim (Lev, 30 µM) and levcromakalim plus glibenclamide (Glib, 2 µM). B) The fractional currents (relative to the maximum current in the absence of ATP; I0) in the presence of diazoxide or levcromakalim are depicted as box and whisker plots. *p<0.05; Student’s t-test.