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. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: Circ Arrhythm Electrophysiol. 2011 Oct 9;4(6):926–935. doi: 10.1161/CIRCEP.111.964643

Figure 6.

Figure 6

Simulation of the effect of KATP channel opening on the action potential duration. A) A numerical model was developed to represent the measured activities of CCS or ventricular KATP channels. Tissue-specific KATP channel models were incorporated into an action potential model of the human ventricle or Purkinje fibers. Shown are effects on the action potential durations caused by KATP channel activation, induced by changing the ATP: ADP ratio (ATP was decreased from 6.4 to 1 mM and ADP was increased from 35 to 180 µM in 10 steps). B) Plot of the action potential duration (measured at −90% repolarization) of the data in Panel A against the ATP:ADP ratio.