Table 3.
Classifying the Atypia Fine Needle Aspiration Cases Using the Four MicroRNAs
| FNA categorya | Risk categoryb | Histological diagnosis | Risk of malignancy (%) | 95% confidence interval (%) |
|---|---|---|---|---|
| Atypia in the training sample set (n=25) | Low risk (n=16) | 6 FA, 1 HA, 7 NH, 1 NNG, 1 FTC | 6.3 | 0.20–30.2 |
| High risk (n=9) | 1 ATC, 4 fvPTC, 2 FTC, 1 PTC, 1 NH | 88.9 | 51.8–99.7 | |
| Atypia in the validating sample set (n=30) | Low risk (n=19) | 6 FA, 2 HA, 1 LT, 3 NH, 3 NNG, 3 FTC, 1 fvPTC | 21.1 | 6.1–45.6 |
| High risk (n=11) | 3 PTC, 1 fvPTC, 3 FTC, 2 FA, 1 HA, 1 NH | 63.6 | 30.7–89.1 |
a
FNA category was based on the Bethesda system for thyroid cytopathology.
b
Risk category was based on the miR prediction results. Low risk: predicted as benign; High risk: predicted as malignant.
FNA, fine needle aspiration.