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. 2010 Jun 4;10(6):5668–5682. doi: 10.3390/s100605668

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© 2010 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Figure 1. — A model for PAS kinase regulation and function. The PAS domain binds to and inhibits the kinase domain. A metabolite (green star) or protein activates PAS kinase by binding to the PAS domain and relieving PAS domain inhibition. This transient activation may be subsequently stabilized through auto- or transphosphorylation. PAS kinase is then competent to phosphorylate substrates involved in glucose partitioning and translation (in S. cerevisiae) to elicit the appropriate physiological response.