Table 2. Echocardiographic post-MI invasive pressure-volume assessments.
| Parameters | Control | CM-BRCA1−/− |
|---|---|---|
| LV end systolic volume (μl) | 5.8±2.4 | 12.8±6.3* |
| LV end diastolic volume (μl) | 7.4±2.9 | 14.1±7.0* |
| LV end systolic pressure (mmHg) | 100±14 | 92±8 |
| LV end diastolic pressure (mmHg) | 23±9 | 19±9 |
| LV ejection fraction (%) | 44.1±15.7 | 21.3±5.4† |
| Cardiac output (μl min−1) | 2206±872 | 1475±467* |
| Stroke work (mmHg × μl) | 307±137 | 164±65* |
| +dP/dt (mmHg s−1) | 6392±1616 | 4817±678* |
| −dP/dt (mmHg s−1) | −5528±1268 | −4101±885* |
|
τ (Glantz, ms) |
16.5±4.4 |
26.2±6.9* |
n=9–11. Data are mean±s.d. with *P<0.05, †P<0.01 versus control (Student's t-test).