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. 2011 Nov 25;12:582. doi: 10.1186/1471-2164-12-582

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Copyright ©2011 Rangel-Salazar et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Epigenetic responses to individual lipoproteins. A, dose-response for global DNA methylation. Solid squares, VLDL; open squares, LDL; solid circles, HDL. 5 mdC, 5-methyldeoxycytosine. For simplicity, significance levels are shown only for highest dose-responses compared to respective controls. B, time-course of global DNA methylation response following stimulation with individual lipoprotein at 91.1 μg protein/ml concentration. Symbols as in A. C and D, effects on histone posttranslational modifications. Significance levels are for comparisons with the respective control. One, two and three stars indicate P < 0.05, P < 0.01 and P < 0.005 significance level, respectively (Scheffé test). Bars, standard deviations.