Table 1.

In vitro antiplasmodial activity, cytotoxicity, and selectivity index of the plant extracts

Plants species	Voucher number	Extract	Antiplasmodial activity (IC50, μg/ml)a		Cytotoxicity MRC-5	Selectivity Indexc
			FCB	3D7	(CC50 μg/ml)b	FCB	3D7
Copaifera religiosa	D. N. 584	CH2Cl2	13.4 ± 3.6	8.5 ± 4.7	4.87 ± 0.5	0.37	0.61
		CH3OH	500.7 ± 16.4	480.9 ± 34.2	NT	ND	ND
Tetrapleura tetraptera	J.J. WIE 6388	CH2Cl2	10.1 ± 3.2	13.0 ± 5.1	79.9 ± 24.3	7.91	6.15
		CH3OH	34.6 ± 4.7	29.6 ± 6.9	89.4 ± 10.8	2.58	3.02
Chloroquine			324.8 ± 16.8 nM	7.9 ± 2.3 nM

a: IC₅₀: (Inhibition concentration 50%) is the drug concentration that reduced parasitemia by 50%

b: CC₅₀: (Cytotoxic concentration drug 50%) is the drug concentration that reduced the number of viable MRC-5 cells by 50%

c: Selectivity index = Ratio CC₅₀/IC₅₀

NT: Not Tested

ND: Not Determined