TABLE 1.

The table represents a compilation of cofactors of RelA/p65 shown to interact via the p65 TAD, together with evidence for these interactions

Data were collected via literature searches. Proline-rich motifs in the interacting regions of the co-factors were identified by hits via the ExPasy Bioinformatics Resource Portal. The E-value is the number of matches with a score equal to or greater than the observed score that are expected to occur by chance. RelA/p65 TAD:co-activator interacting proteins exhibit a proline-rich region in the interface.

Protein	Experiment	Interacting region	PRR in the interacting sequence	E-value	Ref.
A07	In vitro cell-based pull-down assay	C-terminal amino acid sequence 341–459	Pro262-Pro447	1.2 E−2	19
p300	Mammalian two-hybrid system	C-terminal amino acid sequence 1582–2414	Pro1842-Pro2013	2.7 E−11	17
CREB-binding protein (CBP)	Mammalian two-hybrid system	C-terminal amino acid sequence 1892–2441	Pro1878-Pro2064	8.2 E−12	17
			Pro2346-Pro2385	5.9 E−2
TATA box-binding protein-associated factor 80	Co-immunoprecipitation	C-terminal sequence	Pro487-Pro677	6.8 E−05	20
Silencing mediator of retinoic acid and thyroid hormone receptors	Mammalian two-hybrid system	C-terminal amino acid sequence 1060–1495	Pro749-Pro1097	5.3E−17	18
Glucocorticoid-induced leucine zipper	In vitro cell-based pull-down assay	C-terminal amino acid sequence 113–137	Pro115-Pro132		11, 15