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Three SNPs identified in human hypertensive patients are located in the highly conserved CRE and implicated in FSK-induced human RGS2 promoter activity. A, a multiple sequence alignment of RGS2 promoters with highlights of the core sequence of CRE1 (underlined) and three human SNPs. B, promoter assay of WT or mutant 399-bp human RGS2 promoter containing single SNP. Data are represented as mean ± S.E. of four independent experiments. **, p < 0.01; ***, p < 0.001.
