FIGURE 2.

Prolongation of current deactivation after ATP washout for P2X1-2TM chimeras. a, shown are concentration responses to ATP for P2X2 (gray line) and chimeric P2X1-2TM1 and P2X1-2TM2 receptors (n = 3–5). b, shown are time-course of currents evoked by a 3-s application of an EC₇₅ concentration of ATP (P2X2 10 μm, P2X1-2TM1 0.1 μm, P2X1-2TM2 1 μm). ATP was applied for 3 s as shown by the black bar. Traces are normalized to the peak current to highlight the prolonged deactivation for the chimeric receptors on washout of ATP.