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. 2011 Oct 25;286(52):44691–44701. doi: 10.1074/jbc.M111.303917

FIGURE 3.

FIGURE 3.

Swapping both TMs between P2X1 and P2X2 receptors has no effect on the time-course of response. a, shown is a schematic representation of P2X1 (black), P2X2 (gray), and chimeric receptors. b, representative currents mediated by a 3-s application of 100 μm ATP to P2X1 (black dotted line), P2X2 (gray dotted line), and chimeric P2X receptors expressed in Xenopus oocytes. c, a histogram summary shows the percentage of current remaining at the end of a 20-s ATP application. d, shown is a schematic of the reciprocal chimeras on a P2X2 receptor background. e, representative currents are mediated by a 3-s application of 100 μm ATP. f, a histogram summary show the percentage of current remaining at the end of a 20-s 100 μm ATP application. *, p < 0.05; ***, p < 0.001 (n = 3–10).